Although it is well known that astrology played a significant role in Marsilio Ficino’s De vita libri tres, and especially its third book, the De vita coelitus comparanda, the full range of its astrological dimensions has never been satisfactorily explored. In this talk, I will move towards fulfilling this desideratum by describing the three main realms in which Ficino used astrological techniques and ideas towards a medical end—namely, practical astrology, astrological medicine and talismanic magic—within the context of his Platonizing articulation of astrology’s natural philosophical foundations.